PROGRAMME
| Time | Monday, July 27 | Tuesday, July 28 | Wednesday, July 29 | Thursday, July 30 | Friday, July 31 |
| 09:30 - 10:40 | Nothing succeeds like success - Animal Cell Technology Manuel Carrondo, Portugal |
Post- translational modifications Laura Palomares, Mexico |
Purification of biopharmaceutical products Rimenys Carvalho, Brazil |
Stem cell based technologies Stevens Rehen, Brazil |
Development of processes for manufacturing of therapeutic proteins Konstantin Kostantinov, USA |
| 10:40 - 11:00 | Break | Break | Break and "Coral da COPPE" | Break | Break |
| 11:00 - 12:10 | Basic aspects of animal cell cultivation Leda Castilho, Brazil |
Characterization of therapeutic proteins Guillermina Forno, Argentina |
Non-clinical and clinical development of biopharmaceuticals and biosimilars Peter Kalinka, Brazil |
Cell therapies Paula Alves, Portugal |
Development of processes for manufacturing of therapeutic proteins (cont.) Konstantin Kostantinov, USA |
| 12:10 - 13:20 | Development of recombinant cell lines I: constructs, vectors, gene transfer and clone selection Marcos Pinho, Brazil |
Animal cell bioreactors and operation modes Veronique Chotteau, Sweden |
Biotech design facility and the trend to single-use technology Ernesto Chico, Cuba |
Gene therapy Rafael Linden, Brazil |
Biopharmaceuticals: future perspectives and Latin-American experiences Ernesto Chico, Cuba |
| 13:20 - 14:30 | Lunch | Lunch | Lunch | Lunch | Lunch |
| 14:30 - 15:40 | Development of recombinant cell lines II: gene amplification, targeted integration, cell stability Hansjörg Hauser, Germany |
Animal cell separation and cell retention devices for perfusion processes Ricardo Medronho, Brazil |
Regulatory aspects Laura Castanheira, Brazil |
Recombinant vaccines and virus-like particles Laura Palomares, Mexico |
Roundtable: The biopharmaceutical industry in Brazil Biomanguinhos/Fiocruz, Bionovis, Cristália, Libbs, Orygen, Recepta |
| 15:40 - 16:50 | Cell metabolism and cell culture media Francesc Gòdia, Spain |
Cell culture monitoring, modeling and simulation Amine Kamen, Canada |
Antibody-drug conjugates (ADCs) Dyeison Antonow, Brazil |
Vaccine production in animal cell cultures Yvonne Genzel, Germany |
|
| 16:50 - 17:10 | Break | Break | Break | Break | Closing |
| 17:10 - 19:00 | Several workshops will run simultaneously each day. Participants will be divided into small groups to discuss and propose solutions to case studies and technical problems proposed by the lecturers: | ||||
| Aldo Tonso, Brazil Bernardo Moreira and Ricardo Eccard da Silva, Brazil Guillermina Forno, Argentina Hansjoerg Hauser, Germany Marcos Oggero, Argentina Mariela Bollati, Uruguay |
Elisabeth Augusto, Brazil Marcos Oggero, Argentina Marcos Román Calgaro, Brazil Mariana Santos, Brazil Mariela Bollati, Uruguay Rodrigo Martins Bretas, Brazil Stefan Northoff, Germany |
Enio Bassi, Brazil Alvio Figueredo-Cardero, Cuba Bryan Morgan, USA Daniel André Ribeiro, Brazil Laura Castanheira, Brazil Marcelo Nör, Argentina Margareth Ozelo, Brazil |
Greg Hermetet, USA Michael D. Hughson, Brazil Peter Kalinka, Brazil Scott Ross, USA Timo Kejizer, The Netherlands Yvonne Genzel, Germany |
||
CASE STUDY SESSIONS
Monday, July 27
Mon1: Monitoring respiration rate, Aldo Tonso, University of São Paulo, Brazil
Mon2: Biosimilar development overview, Bernardo Moreira and Ricardo Eccard da Silva, ANVISA - Brazilian Health Surveillance Agency, Brazil
Mon3: Application of “Quality by design” concepts to the development of biopharmaceuticals, GuillerminaForno, National University of Litoral, Argentina
Mon4: Instability of CHO cells: friend and foe, Hansjoerg Hauser, Helmholtz Institute for Infection Research, Germany
Mon5: Designing immunochemical methods for the production of animal cell culture-derived biotherapeutics, Marcos Oggero, National University of Litoral, Argentina
Mon6: Tips for the generation of stable cell clones using high speed cell sorting, Mariela Bollati, Pasteur Institute of Montevideo, Uruguay
Tuesday, July 28
Tue1: Modelling of animal cells processes,Elisabeth Augusto, Federal University of São Paulo, Brazil
Tue2: Rational engineering of novel protein-based therapeutics by adding potential N- and O-glycosylation sites, Marcos Oggero, National University of Litoral, Argentina
Tue3: Economic comparison between stainless steel and single-use systems, Marcos RománCalgaro, Thermofisher, Brazil
Tue4: Strategies for clone detection, selection and isolation, Mariana Santos, Butantan Institute, Brazil
Tue5: Application of flow cytometry to study and characterize cell growth, metabolism and death (apoptosis), Mariela Bollati, Pasteur Institute of Montevideo, Uruguay
Tue6: Setting up testing programs for the characterization and qualification of different cell lines used to manufacture biologicals,Rodrigo Martins Bretas, ANVISA - Brazilian Health Surveillance Agency, Brazil
Tue7: Media development – Considerations, challenges and solutions,Stefan Northoff, Xell AG, Germany
Wednesday, July 29
Wed1: Practical demonstration of CHO cells viability analysis using flow cytometry and an overview of other possible applications in biotechnology and bioprocesses, EnioBassi, BD, Brazil (at the laboratory)
Wed2: Biorreactor operation modes for industrial animal cell culture purpose, AlvioFigueredo-Cardero, Center for Molecular Immunology, Cuba
Wed3: Tuning techniques for bioprocessing vessel controllers, Bryan Morgan, Finesse Solutions Inc., USA
Wed4: Development and scale-up of a protein purification process (basic principles), Daniel André Ribeiro, Biomanguinhos/FIOCRUZ, Brazil
Wed5: Regulatory approach for monoclonal antibodies with clinical indication for autoimmune diseases and oncology: quality issues related to comparability exercise, reduced clinical programs, extrapolation of indications and considerations related to substitution, Laura Castanheira, Hemobras, Brazil
Wed6: Basis on design of "single-use systems", Marcelo Nör, Pall Corporation, Argentina
Wed7: How to elaborate a clinical trial forbiosimilars and innovator biologics, MargarethOzelo, University of Campinas, Brazil
Thursday, July 30
Thu1: Fixed-bed perfusion bioreactors, Greg Hermetet, Pall Corporation, USA
Thu2: Affinity Chromatography: a brief introduction and case study, Michael D. Hughson, Federal University of Rio de Janeiro, Brazil
Thu3: EPO case study: development of a biosimilar of AmgensEpogen, Peter Kalinka, Bionovis, Brazil
Thu4: Applying an integrated design approach to create a novel high performance fed-batch media system for mammalian cells, Scott Ross, Sigma Aldrich, USA
Thu5: Scale down characterization of the BioSep, an acoustic cell retention device for continuous cell cultures, TimoKejizer, Applikon Biotechnology, The Netherlands
Thu6: Deciding on cultivation vessel & process strategy for cell culture-based viral vaccine production, Yvonne Genzel, Max Planck Institute Magdeburg, Germany
Social programme:
On Thursday (July 30) there will be a dinner at a churrascaria. The special bus will take participants to the restaurant. More information will be posted at this website soon.
SPONSORS
